Cleanroom Testing and Validation Instruments

Liquid Particle Counter

A light-obscuration liquid particle counter for repeatable sizing and enumeration of sub-visible particles in pharmaceutical and process-liquid samples.

Metered liquid volumes support repeatable sample counts.
Light obscuration resolves multiple particle thresholds.
Small samples and automated rinsing limit material use.

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Product Introduction

This liquid particle counter draws a controlled sample volume through a laser light-obscuration sensor, where individual particles are sized from the reduction in transmitted light. A precision syringe or piston sampling system supports repeatable volume delivery, while programmable test routines manage flush, measurement and reporting steps. Interchangeable sensor ranges allow the platform to address parenteral products, purified water, solvents, oils and other compatible liquids.

Key Features

Volumetric sampling controls the exact liquid volume used for each particle result.

Light-obscuration sensing provides simultaneous particle counts across multiple size thresholds.

Small-volume probe options reduce product consumption for high-value formulations.

Automated flush routines limit carryover between samples and reduce manual handling.

Bubble and sensor-condition alerts help distinguish sampling faults from genuine particle events.

Configurable methods store sample volume, replicates, thresholds and reporting calculations together.

Customer Product Concerns

Reliable liquid counts require bubble control, thorough carryover removal between samples, and repeatable results from the smallest practical volume of costly product.

Air bubbles can be counted as particles and inflate the reported result.Controlled sample preparation, bubble detection and stable volumetric aspiration reduce bubble-related false events.

Residue from a previous high-count sample can contaminate the next test.Programmable flush volumes and a short cleanable flow path provide a defined carryover-control sequence.

High-value biologic samples may not be available in large volumes.Small-bore probes and low-volume methods can perform meaningful measurements with minimized sample consumption.

Different liquids vary in viscosity and optical properties.Selectable sensor, flow rate and method settings adapt the sample path to compatible formulation characteristics.

Typical Applications

Sub-visible particle testing of injectable and infusion productsParticle monitoring in purified water and water-for-injection samplesCleanliness assessment of process chemicals and solventsHydraulic oil, lubricant and fuel contamination analysisResearch and formulation troubleshooting for protein-based products

Technical Parameters

The table summarizes representative analyzer, probe, flow-path, and sample-interface materials and dimensions for a liquid counter, with selection based on viscosity, sample volume, and particle-size thresholds.

Core Material	Powder-coated or stainless instrument enclosure with a glass-and-stainless sampling path, precision syringe assembly and laser sensor
Panel Thickness	Typically 1.0–1.5 mm enclosure panel thickness
Effective Width	Approximately 300–360 mm according to sampler configuration
Maximum Length	Approximately 330–500 mm including sample probe and syringe mechanism
Steel Facing Thickness	Approximately 1.0–1.5 mm where stainless enclosure panels are specified
Core Density	Not applicable; no insulation core is used (0 kg/m³)
Thermal Conductivity	Approximately 14–16 W/(m·K) for stainless wetted and enclosure components
Surface Finish	Smooth light-gray wipe-clean coating with passivated stainless and glass sample-contact surfaces
Joint Type	Luer or compression sample probe connection with removable sensor tubing and waste outlet
Customization	Available based on the intended application and operating environment.

Available Options

Sensor ranges from approximately 1.3–150 µm or application-specific alternativesLow-volume pharmaceutical sample probeBottle, syringe or online sampling configurationAutomated rinse and waste handlingPharmaceutical or industrial reporting softwareSample holders for vials, bottles and bags

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