Laminar Flow and Containment Equipment

Negative-Pressure Containment Isolator

A general-purpose negative-pressure process glovebox configured around potent, sensitizing or dusty materials that must remain separated from operators and the room.

Inward Leakage Direction
Process-Specific Glove Layout
Closed Ingress and Egress
Safe-Change Exhaust Options

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Product Introduction

This isolator is a configurable containment platform rather than a pharmacy-specific unit. The welded chamber operates below room pressure, and process equipment, feed chutes or balances can be integrated inside the glove-access work zone. Materials enter and leave through transfer hatches, split valves, continuous liners or other sealed connections selected for the process. Staged exhaust filtration and contained maintenance interfaces keep collected particulate within the barrier system.

Key Features

Negative chamber pressure sets any leakage direction toward the contained process.

Glove and equipment positions are arranged around the actual process sequence.

Multiple transfer technologies can connect source, receiver and waste routes.

Safe-change filters reduce contact with collected particulate during service.

Welded radiused surfaces support dry cleaning, wipe-down or selected wash methods.

Customer Product Concerns

Containment performance depends on the process interfaces and maintenance route as much as on the chamber pressure itself.

The chamber is sealed but source containers connect through an open chute.A selected closed transfer interface continues the barrier to the source vessel.

Glove ports do not align with installed process equipment.Reach studies position ports, supports and controls before chamber fabrication.

Filter change becomes the highest-exposure maintenance task.Bag-in/bag-out or push-through filter housings contain the loaded stage.

One cleaning method is specified for every material.Surface finish, drainability and wash features are matched to the actual product and campaign.

Typical Applications

Potent API processingSensitizing powder handlingContained laboratory-scale manufacturingHazardous sample subdivision

Technical Parameters

Typical configurable construction ranges for a negative-pressure containment isolator are listed below.

Core Material	Fully welded SUS316L process chamber with safety glass, CSM glove assemblies and staged containment filtration
Panel Thickness	50-120 mm double-skin process and filter sections
Effective Width	1200-5000 mm usable process width
Maximum Length	Up to 8000 mm overall isolator length
Steel Facing Thickness	2.0-4.0 mm SUS316L chamber shell; 1.2-2.0 mm service skins
Core Density	Approximately 8000 kg/m³ for SUS316L structural material
Thermal Conductivity	14-16 W/(m·K) for austenitic stainless steel
Surface Finish	Fine-brushed or electropolished SUS316L with welded radiused internal transitions
Joint Type	Pressure-tight welded chamber with sealed glove ports, flanged process connections and safe-change filters
Customization	Available based on the intended application and operating environment.

Available Options

Split valve or continuous linerIntegrated balance or process equipmentWash-in-place spray systemRemote technical-side filter service

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